Side-effects study opens up new drug leads
source: http://www.rsc.org/chemistryworld/News/2008/July/11070801.asp
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Existing drugs could be used to treat a broader range of diseases, according to scientists in Germany and Denmark, who have predicted drug targets by using side-effects data on medication labels.
As well as binding to their intended target, drugs also interact with other proteins in the body triggering side-effects. By comparing chemically dissimilar drugs that have the same side-effects, the team predicted additional targets for 20 pairs of drugs that are already on the market. They tested the effects of nine of these drugs on cultured cells, showing that their predictions were correct.
As well as binding to their intended target, drugs also interact with other proteins in the body triggering side-effects. By comparing chemically dissimilar drugs that have the same side-effects, the team predicted additional targets for 20 pairs of drugs that are already on the market. They tested the effects of nine of these drugs on cultured cells, showing that their predictions were correct.
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