Community | February 07, 2009 | 35 comments

Recent Research on Medical Marijuana

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simplecj
Despite the ongoing political debate regarding the legality of medicinal marijuana, clinical investigations of the therapeutic use of cannabinoids are now more prevalent than at any time in history. A search of the National Library of Medicine's PubMed website quantifies this fact. A keyword search using the terms "cannabis, 1996" (the year California voters became the first of 13 states to allow for the drug’s medical use under state law) reveals just 258 scientific journal articles published on the subject during that year. Perform this same search for the year 2008, and one will find over 2,100 published scientific studies.

While much of the renewed interest in cannabinoid therapeutics is a result of the discovery of the endocannabinoid regulatory system, some of this increased attention is also due to the growing body of testimonials from medicinal cannabis patients and their physicians. Nevertheless, despite this influx of anecdotal reports, much of the modern investigation of medicinal cannabis remains limited to preclinical (animal) studies of individual cannabinoids (e.g. THC or cannabidiol) and/or synthetic cannabinoid agonists (e.g., dronabinol or WIN 55,212-2) rather than clinical trial investigations involving whole plant material. Predictably, because of the US government's strong public policy stance against any use of cannabis, the bulk of this modern cannabinoid research is taking place outside the United States.

As clinical research into the therapeutic value of cannabinoids has proliferated – there are now more than 17,000 published papers in the scientific literature analyzing marijuana and its constituents — so too has investigators' understanding of cannabis' remarkable capability to combat disease. Whereas researchers in the 1970s, 80s, and 90s primarily assessed cannabis' ability to temporarily alleviate various disease symptoms — such as the nausea associated with cancer chemotherapy — scientists today are exploring the potential role of cannabinoids to modify disease.

Of particular interest, scientists are investigating cannabinoids' capacity to moderate autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease, as well as their role in the treatment of neurological disorders such as Alzheimer's disease and amyotrophic lateral sclerosis (a.k.a. Lou Gehrig's disease.)

Investigators are also studying the anti-cancer activities of cannabis, as a growing body of preclinical and clinical data concludes that cannabinoids can reduce the spread of specific cancer cells via apoptosis (programmed cell death) and by the inhibition of angiogenesis (the formation of new blood vessels). Arguably, these latter trends represent far broader and more significant applications for cannabinoid therapeutics than researchers could have imagined some thirty or even twenty years ago.

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35 comments // Recent Research on Medical Marijuana

  • poptart_invasion
    • 0
      poptart_invasion  
    • usually on issues such as gay rights, i think all will be better once the old gaurd, slowly but surely, dies out.
      but this issue is different. yeah, the old gaurd will die out, but not until countless others die at the hands of dealers, gangbangers, and drug lords who profit off prohibition. its disgusting to hear fanatics rail on about the imaginary evils of the drug while ignoring the evil that their shortsightedness breeds.
      and for the record, im not a user.
      oh, and simplecj, the one possible flaw that i saw was to insinuate that it doesnt cause brain damage. of course, recent reasearch may have disproved that, but i havent seen it, though it obviously helps more than it hurts.
      no more danerous than liquer or cigarettes.

    • 3 years ago
  • jubal
  • simplecj
    • 0
      simplecj  
    • I have been waiting 12 years for these laws to change. Ever since I started smoking it, I've have known the truth about how harmless cannabis is. Over the years I have learned a multitude of reasons why it's illegal [money, greed, racism, power, corruption] as well as why it really shouldn't be.

      You may think this isn't an important issue and that we've got bigger things to deal with, but I disagree with you. The implications of prohibition are far reaching and profoundly unjust especially in the case of cannabis.

      Back in 2001 I ended up locked in jail with murderers and meth addicts for three fucking months, humiliated by having to piss in front of a cop, repeatedly strip searched and handcuffed like I was some kind of animal. In total I lost possession of about two years of my life and thousands of dollars.. what was my offense? I sold a $10 sack to a kid wearing a wire, what I saw at the time and still do see as a victimless crime of a tiny magnitude. I mean 1.3 grams of some harmless herb and I lost all my rights, was labeled a felon and went through hell personally and with my family members.

      Is this justice? I was certainly no criminal. I was your average 20 year old, 2 years out of high school and attending a full time machinist program at the local tech center, which I finished shortly before jail. I had overwhelming support in the form of letters of character reference from everyone including my principle and you know what they told me? "We think [simplecj] needs to realize the seriousness of what he's done. We recommend 90 days jail time, up to 3 years probation with weekly piss tests, completion of out-patient drug rehabilitation, plus $1000 fine and restitution.

      SO, now I'm a 28 year old who regularly smokes (since the day I got my termination papers), I'm happily married and about to graduate from 6 years in the engineering program at my local university with a 3.45 GPA (one of the highest in my class).

      I was a virtual POW in this pointless war and I'm really pissed off that it continues to happen to hundreds of thousands of people every year despite the mountain of evidence that not only vindicates cannabis as a recreational substance, but goes much much farther in praising the plant for it huge varieties of uses; from medicine to fuel for our cars, healthy foods, durable clothing, building material... the list just goes on and on.

      IT'S TIME FOR THE INSANITY TO STOP!!

      We need to end prohibition just as Nixon's Shafer Commission recommended back in 1972. The injustice and ignorance has become disgusting and saying this isn't an important issue is outright insulting to anyone who knows the hardships good people have gone through because of our draconian laws.

      This travesty goes way beyond our borders and is actually been aiding in the oppression and persecution of many people around the globe. We've set the example of a police state and have expected other nations to follow suit, and they have... enough is enough! It's time to restore the staple crop of civilizations from ancient China to the early United States, we need it now more than ever!!

    • 3 years ago
  • simplecj
    • 0
      simplecj  
    • To those who say they're tired of seeing this topic on Current because they think it's just a bunch of hippies who want to get high:

      Well you clearly don't understand that this battle isn't, by far, only for the ability for a minority to get stoned without fear of arrest.

      This is about safe and effective medicine, clean renewable resources, ending the violence at the Mexican border, greatly reducing the power and profits of criminal organizations, generating BILLIONS of tax revenue, creating millions of new jobs, stimulating the farming industry, increasing availability of healthy hemp seed foods, ending the global oppression and misinformation campaign against cannabis and hemp, offering a viable means of cleaning toxic land-spills, possibly finding a cure for cancer and other horrible diseases, and on and on and on...

      What I'm tired of is people who want to just disregard the push for ending prohibition as just a bunch of hippies who want to get high. We already get high, what we're fighting for is JUSTICE AND A BETTER FUTURE FOR ALL!!!!

      Perhaps we need to widen our platform though. Current does seem to have a good majority of people who agree with ending prohibition. If everyone agrees then who is enlightened? Although I would hope that what we post on here gets posted other places as well by people who like what they see. This is why it's important to share these videos. Post them on MySpace, Facebook, where ever there are people who need to be confronted with truth, that is where we need to be putting this information!

      Anyone know of any other good social news sites like Current??

    • 3 years ago
  • Herbal_Minded
  • jubal
  • kramericus
  • Wrabon
  • rockinrandy1965
    • 0
      rockinrandy1965  
    • RED LIGHT DISTRICTS
      should be put( or voted) in every major city. If privileged rights are carried outside the zone : Serious punishment should be enforced’ But not to the : extreme of link below

      NORML News – January 9, 1998www.druglibrary.org/olsen/norml/WEEKLY/98-01-09.html - 25k -http://www.druglibrary.org/olsen/norml/WEEKLY/98-01-09.html - 25k
      Pending Mississippi Bill Threatens Dismemberment For Convicted Drug Violators ... found guilty of possessing marijuana in Mississippi could face the removal of a limb if ... NORML estimates that between $7.
      The war on products that are consumed for pleasure are now taxed : government like taxes. But that puts people out of business. People warehouses, lawyers,judges ect. The money from not paying prison guards and the likes are therefor spent in rehabilitateing educating and treating mental illness for what it is addiction. We can give this a try. Just say no......dose nott work.. did not work will not work Through our penitentiary system, they and thats most of whom are in the system (addicts) enter prison with bachelor of marawana come out with a doctorate of cacaine .Im not promoting endorsing and thinking this is the greatest idea but I believe in freedom and choice and helping instead of punishing. Think , we would have less criminals so public safety would increase.
      Conservatives need to get off there ass and outside the box, they been inside our box up the ass for to long . this subject runs deep and it has reamed and ravished those who happened to become addicted to an illegal substance. Ill say alcohol and leave it at that...government picked a hell of a killer to make that one legal..But that was another war (prohibition )call it world war
      1http://current.com/users/rockinrandy1965/all/0.htm

    • 3 years ago
  • nursediesel
    • 0
      nursediesel  
    • I still have a theory... it's the Dupont's... all their money and position stopped hemp products because they wanted all the rope used in industrial applications to be their synthetic rope... check it out.

    • 3 years ago
  • simplecj
    • 0
      simplecj  
    • nursediesel:

      It's not really a theory, but a all but provable fact. It wasn't just rope though, DuPont had come out with materials for clothing and other product for their paint that could be substituted with hemp products. They along with the cotton, lumber and oil companies all stood to lose from the competition with hemp, so with the help of racist freedom haters who just happened to have the political and media power to do so, launched a campaign to lie to the public and force cannabis and hemp out of the mainstream and into the law books.

      If I only had a time machine... Anslinger and Hearst would be my first targets!

    • 3 years ago
  • rockinrandy1965
  • Wrabon
    • 0
      Wrabon  
    • Image
    • nursediesel:

      You are right, Robert L. DuPont, M.D. company slogan is "Creating Tomorrow's Drug Policy" His family makes the drug test and his company lobbies for the drug war and is trying to get the Feds to pay them to drug test all the kids in schools in the US. From their own website, they clam that 25% of the student will test positive and should be punished like they feel "Phelps Shouldn't Get a Pass".

      The DuPont family will destroy America!

      Here is their website Please sent hate mail!
      http://www.ibhinc.org/index.html

    • 3 years ago
  • davzap
  • bailey78
  • jay_oh_aych_en
  • prg
    • 0
      prg  
    • The big drug companies thrive off of keeping people ill. The prison system makes big money with the current laws. It is criminal that these two industries can toy with human life like this. What discuses me is how the people who operate these corporations parade around in their power suits, fancy offices & lifestyles and common folk look up to them as if they deserve our respect.

    • 3 years ago
  • ZomOn
  • simplecj
  • ZomOn
    • 0
      ZomOn  
    • ZomOn:

      we appreciate your honesty about our music. no worries country isnt for everyone. We are just simple country boys having a good time and protesting the unjust laws which continue to cause great instability in our country. We know there are plenty of more pressing issues our country is dealing with yet everyone has a role in this 21st Century. Fighting for a stronger balance to prevent more of the great injustices that have been place on our fellow citizens because of herb is only one of ours

    • 3 years ago
  • torybart
    • 0
      torybart  
    • There really isn't anything else we can say. It's pretty obvious that our drug war is a complete failure and the prohibition of marijuana is one of the most destructive and irresponsible laws in effect.

      All we need now are high paid lobbyists...

    • 3 years ago
  • unimatrix0
    • 0
      unimatrix0  
    • Image
    • great resources simplecj - good job

      marijuana reform should be everyones priority

      Prohibition does not work; prohibition is a historical and contemporary failure.

      Marijuana should be legalized, taxed and regulated for medical and recreational purposes.

      Drug use and abuse should be treated as a medical problem, rather than a criminal problem.

      All those incarcerated for non violent drug violations should be released immediately.

      The war on drugs is a war on Americans. Let us end the assault on our friends and neighbors.

    • 3 years ago
  • simplecj
    • 0
      simplecj  
    • Come on Obama, you can't have rational policy and end wasteful spending without addressing this primary problem with the drug war; it's focus on the harmless and often helpful cannabis sativa... this is change we WANT!!

    • 3 years ago
  • simplecj
  • simplecj
  • simplecj
  • MeganAlexis
  • simplecj
  • simplecj
  • simplecj
  • simplecj
    • 0
      simplecj  
    • So why the hell is cannabis still considered a schedule 1 narcotic? Who do they think they're fooling?? ... well, besides all the ignorant Americans who still think cannabis is the Devil's weed that causes brain damage, and makes you insane.

      Every argument against ending cannabis prohibition I've ever heard is completely lacking in any real substance or rational thinking, while at the same time completely ignoring a mountain of evidence that suggests otherwise... what's the word for this??

      Insanity? Irony? Hypocrisy? Crime against humanity?? Just plain fucking stupid? I feel like the nation has slowly been smashing their heads into a wall trying to achieve rational cannabis policies and point out the failure of the Drug War. How many head's banging on that wall is going to take to break through?? When will we see leaders who aren't afraid to challenge flawed and unjust policies, ones that were founded on a campaign of lies, deceit, racism and greed?? How long can they continue to uphold their weakening house of cards??

      This is just so frustrating... why is the government treating cannabis like the elephant in the room?

    • 3 years ago
  • alivein85
  • simplecj
  • prg
    • 0
      prg  
    • simplecj:

      I hear you...the #1 job of the drug czar is not to win the war on drugs (whatever that means), but to continue funding in the billions of $$ for the (phony) war on drugs.

    • 3 years ago
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