Community | March 17, 2010 | 81 comments

Cannabinoids promote hippocampus neurogenesis and other positive mental effects

source: http://www.jci.org/articles/view/25509

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tbowman131
how will the media spin this? or will they just ignore it? at the very least, it's time to legalize medical marijuana nationwide...

"In summary, since adult hippocampal neurogenesis is suppressed following chronic administration of opiates (20), alcohol (21), nicotine (22), and cocaine (23), the present study suggests that cannabinoids are the only illicit drug that can promote adult hippocampal neurogenesis following chronic administration. Increased hippocampal neurogenesis appears to underlie the mechanism of anxiolytic- and antidepressant-like effects produced by a high dose of chronic HU210 treatment. The opposing effects of high doses of acute and chronic cannabinoids, together with the anxiolytic-like effects caused by a low dose of cannabinoids, may finally explain discrepancies in the clinical study literature regarding the effects of cannabinoid on anxiety and depression."
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81 comments // Cannabinoids promote hippocampus neurogenesis and other positive mental effects

  • DarkEnergy
    • 0
      DarkEnergy  

    • OPPRESSIVE REGIMES NO MORE!
      So now it will come to pass, we can all mow the grass!
      My body likes it. My body doesn't like alcohol. My brain has cannabinoid receptors but does not have tobacco, alcohol or firearm receptors.
      Well, don't tell that to my XD9 and friends!
      STAY TOONED...

    • 1 year ago
  • GodsnLiberals
    • 0
      GodsnLiberals  
    • Image

    • http://cyber.law.harvard.edu/evidence99/marijuana/Health_1.html

      ">>>>The most potent argument against the use of marijuana to treat medical disorders is that marijuana may cause the acceleration or aggravation of the very disorders it is being used to treat.

      Smoking marijuana regularly (a joint a day) can damage the cells in the bronchial passages which protect the body against inhaled microorganisms and decrease the ability of the immune cells in the lungs to fight off fungi, bacteria, and tumor cells. For patients with already weakened immune systems, this means an increase in the possibility of dangerous pulmonary infections, including pneumonia, which often proves fatal in AIDS patients.

      Studies further suggest that marijuana is a general "immunosuppressant" whose degenerative influence extends beyond the respiratory system. Regular smoking has been shown to materially affect the overall ability of the smoker�s body to defend itself against infection by weakening various natural immune mechanisms, including macrophages (a.k.a. "killer cells") and the all-important T-cells. Obviously, this suggests the conclusion, which is well-supported by scientific studies, that the use of marijuana as a medical therapy can and does have a very serious negative effect on patients with pre-existing immune deficits resulting from AIDS, organ transplantation, or cancer chemotherapy, the very conditions for which marijuana has most often been touted and suggested as a treatment. It has also been shown that marijuana use can accelerate the progression of HIV to full-blown AIDS and increase the occurrence of infections and Kaposi�s sarcoma. In addition, patients with weak immune systems will be even less able to defend themselves against the various respiratory cancers and conditions to which consistent marijuana use has been linked, and which are discussed briefly under "Respiratory Illnesses."

      In conclusion, it seems that the potential dangers presented by the medical use of marijuana may actually contribute to the dangers of the diseases which it would be used to combat. Therefore, I suggest that marijuana should not be permitted as a therapy, at least until a good deal more conclusive research has been completed concerning its debilitating effect on the immune system.

      For more on this topic, please see Donald P. Tashkin, M.D., "Effects of Marijuana on the Lung and Its Immune Defenses," Secretary's Youth Substance Abuse Prevention Intiative: Resource Papers, March 1997, Center for Substance Abuse Prevention. Pages 33-51 of this address can be found at the website of the Indiana Prevention Resource Center at Indiana University>>>>>>>>>>>...........".

    • 1 year ago
  • handbanana89
    • +1
      handbanana89  
    • GodsnLiberals:

      Haha, copy and paste. Your examples are a mimicry of other's ideas.

      Marijuana can aggravate some disorders, but like any treatment, this is why one should consult a doctor before attempting to self heal/medicate in any way shape or form. That seems like common sense to me.

      Honestly, you are breathing in soooo many more toxic substances than marijuana right at this moment. There is no denying smoking anything is somewhat harmful. That remains as old news and again, common sense.

      Blah, blah. 'immunosuppressant' all of this is so vague and there are no conclusive studies to support this. People not receiving adequate treatment and taking hundreds of pills in attempt to fight these diseases is already hell on the immune system.

    • 1 year ago
  • handbanana89
    • 0
      handbanana89  
    • handbanana89:

      All in all. You simply copy and pasted some random article. All of this is so arbitrary and i'm not sure what point you're trying to make. People that have an illness have weakened immune systems?

    • 1 year ago
  • Vierotchka
    • +1
      Vierotchka  
    • GodsnLiberals:

      Smoking is not the only way to consume cannabis. I make tchai with it, delicious, and the effects last much longer, too. Then, there is cannabis oil (that's the therapeutic preparation which cures a great many diseases including many cancers), and, of course, cannabis brownies!

    • 1 year ago
  • satan_lucifer
    • 0
      satan_lucifer  
    • GodsnLiberals:

      This is all bullshit manufactured by those ruled by fear and insecurity and bought and paid for by the evil that uses them as a tool. If any of this were true, I and thousands, possibly millions would by in terrible condition or dead, but we are not. I am living proof that it is excellent for the human body and I am willing to submit to any testing to the contrary. They can come up with statistics until the cows come home and they will still be wrong. Besides, they can be as pias and condescending as they want when they're getting all that money from drug companies. Smoking is not the only way to take it and if I took what these idiots said seriously, I would be dead and crippled along time ago. But I am not! It is this kind of finely manufactured crap that is presented to rule people by fear and insecurity, that poisons the world! You have to ask yourself the glaring question? If it's that bad, then why do so many people do it? At least it doesn't have a major bodily damage and death as side effects! I can't wait until it's legal and you self absorbed idiots are blown out of reality!!!!!!

      FUCK YOU!!!!!!!!!!!!!!!!

      S.

    • 1 year ago
  • satan_lucifer
  • Vierotchka
  • satan_lucifer
  • GodsnLiberals
  • tbowman131
  • satan_lucifer
  • StephenJohnson
  • GodsnLiberals
    • 0
      GodsnLiberals  
    • StephenJohnson:

      a liberal educated boss?? kinda like a unicorn and batman..

      by the way my highly educated liberal counterpart..does this mean you dont have any say about the issue at hand or your just here watching poorly educated losers??

    • 1 year ago
  • handbanana89
  • GodsnLiberals
  • PirateSauce
  • Conniepae
    • +1
      Conniepae  
    • PirateSauce:

      That's exactly what I was thinking. I have never flagged anyone, but I am going to flag all his comments which are really just insulting rhetoric. I'm sick of reading what he types. If we argue with him, we will be making personal attacks, which is against the rules at current. I think flagging this moron is our only option. You can't 'reason with the ignorant'.

    • 1 year ago
  • GodsnLiberals
  • GodsnLiberals
  • handbanana89
  • buddahla
    • 0
      buddahla  
    • GodsnLiberals:

      Ah, improvement...this time you waited a full four posts before returning to your signature "I'm-such-a-superior-wanker" line of "weak minds yada yada."

      really, pick the needle up off the record and find a new vinyl that doesn't skip, doesn't skip, doesn't skip, doesn't skip, doesn't skip, doesn't skip, doesn't skip, doesn't skip

      Weak minds copy and paste because they have no cohesive thoughts of their own.
      Weak minds repeat the same mantra over and over again, because familiarity is their best security in a world that frightens them.

    • 1 year ago
  • GodsnLiberals
  • StephenJohnson
    • +2
      StephenJohnson  
    • GodsnLiberals:

      Oh the fifth of whiskey had nothing to do with it!

      Truth be known, with the parents passed out DRUNK the other kids could have put the baby in the oven playing. That would be a good reason why the door was not completely shut and the oven not turned on. Then when the shit hit the fan the kids blamed the drunk step-dad. He said he doesn't remember, because he was passed out DRUNK. Mom said he must have did it because I was passed out DRUNK. That's one good way to get rid of a DRUNK worthless step-dad!

    • 1 year ago
  • Incredulous
  • GodsnLiberals
  • MindsiMedia
    • 0
      MindsiMedia  

    • Anybody interested in the history of our drug laws should look for the book "Drug War" by Dan Russell which is an excellent resource.

    • 1 year ago
  • StephenJohnson
    • +3
      StephenJohnson  

    • Well here is one for the big baby using human brain cells!

      http://www.thesethgroup.org/

      "Using the same tests used to judge new chemotherapies, the SETH team discovered that this herbal compound kills human brain tumor cells at a concentration that is nontoxic to normal brain cells.

      The major active component of the medicinal plant cannabis, Δ9-THC, has been shown in experiments with rats to have therapeutic potential against brain tumors. SETH Group scientists Garret Yount, Ph.D. and Sean McAllister, Ph.D. performed parallel experiments testing the effect of Δ9-THC on human brain cancer cells (glioblastoma multiforme, or GBM) and also on normal brain cells. Putting this herbal compound through the same tests that a new chemotherapeutic agent would go through revealed a potent and remarkably specific anti-cancer effect. Both types of cells were treated with the same concentration of Δ9-THC but after 20 hours only the cancer cells died. Cell death is seen in the lower right panel as cells shrinking to inanimate white spheres.

      No chemotherapy can match this nontoxic anti-cancer action. The implication is that this plant compound could be a safe medicine against brain tumors, without the side effects of chemotherapy. "

      Sean McAllister, Ph.D. is a molecular pharmacologist at California Pacific Medical Center Research Institute.

      Garret Yount, Ph.D. is a molecular biologist and works as a director of a molecular and cellular biology laboratory at the California Pacific Medical Center Research Institute.

      http://www.youtube.com/watch?v=3OqSRfzqwWA

    • 1 year ago
  • GodsnLiberals
    • -3
      GodsnLiberals  

    • I ask everybody in here..you guys crusade behind medical marijuana..how many of you people are actually sick and how many are just simple dope fiends??????

      I am not expecting you guys to tell me..ask youself that..because i would say a huge % of dope fiends would eventualy end up COMPLAINING that the whole world does not end at thier command..and if I cant give it fast enough or if i dont pay huge amount of taxes to support his ass..then im a racist or facist..

      THAT IS WHAT IS HAPPENING NOW..AND MOST OF THESE DOPE FIENDS ARE TOO WEAK MINDED TO REALIZE THAT

    • 1 year ago
  • StephenJohnson
  • Incredulous
    • +3
      Incredulous  
    • GodsnLiberals:

      I am neither, but I am an adamant supporter of Constitutional rights, and the government has no business telling people what they can and cannot grow in a flower pot or their vegetable garden. Commercial production of any crop is a different story, but the criminalization of any plant is just stupid, and the amount of money we spend keeping these plants illegal is beyond stupid.

    • 1 year ago
  • MindsiMedia
  • GodsnLiberals
    • -1
      GodsnLiberals  
    • StephenJohnson:

      hey I am not the one who ends up in an "durg intervention program" or "rehab" with a boo hoo story hoping for the world to have pity on my ass..

      fact remains..people who rely on DOPE are weak minded people..dependent leeches who wants people to take care of them..hence the current mindset of those dope users..

      prove me wrong.. tell me one dope success story..

      i have one on my side of the argument:

      http://current.com/1c2fc4c

    • 1 year ago
  • GodsnLiberals
    • -2
      GodsnLiberals  
    • MindsiMedia:

      what i am saying is not hatred but fact..okay so you dont want me to call his a 'dope feind" should i say "dope dependent"? does that make it less dramatic??

      wake up..drug use makes people weak minded..

    • 1 year ago
  • StephenJohnson
    • +2
      StephenJohnson  
    • GodsnLiberals:

      Well you got astrophysicist Carl Sagan, Bill Clinton, George Bush, Obama, Schwarzenegger, fish-boy Phelps, Willie Nelson, Snoop, Sir Richard Branson, Rick Steves, Michael Bloomberg, Ted Turner, Montel Williams, Stephen King, Paul McCartney, Richard Feynman, Stephen J. Gould, Milton Friedman and don’t forget William F. Buckley. Along with millions of ever day Americans! Just to name a few!

      Looks like you are the weak minded LOSER again!

    • 1 year ago
  • Capicuaman
  • Conniepae
    • +2
      Conniepae  
    • GodsnLiberals:

      I hate to break it to you, but you really aren't that damn important. You are just a person who wants to jump into a conversation, to spout your rhetoric. You bring nothing to the discussion. Some of us are old enough to know bickering with someone who knows nothing about the subject is a waste of time and energy. Move along.

    • 1 year ago
  • GodsnLiberals
    • 0
      GodsnLiberals  
    • Conniepae:

      what i am bringing into this conversation is the fact that there are several side effect to this study...

      and that it is done to rats and mice

      SO DONT JUMP INTO THIS IDEA THAT IT SHOULD BE LEGALIZED ..

      STOP SMOKING DOPE LONG ENOUGH TO COMPREHEND THAT..

    • 1 year ago
  • handbanana89
  • GodsnLiberals
    • -4
      GodsnLiberals  

    • and I hope these DOPE FIENDS would realize that this study was not conducted NOT done using human subject..they nit pic on the results...

    • 1 year ago
  • davzap
    • 0
      davzap  

    • Its great that they can explain in technical terms exactly why we enjoy pot.
      Cannabis is becoming the new wonder drug with its ability to kill cancer growth and its psychologic quality. All around good for you herb.

    • 1 year ago
  • GodsnLiberals
    • -2
      GodsnLiberals  
    • davzap:

      this is a study that does not prove shit...not unless you have a rat brain.. and read the entire article because it seems like your wonder DOPE has its side effects..(which most of these dope fiends tend to ignore)

    • 1 year ago
  • Vierotchka
    • +1
      Vierotchka  

    • The article states that "However, marijuana has been the most commonly used illicit drug in developed countries, producing acute memory impairment and dependence/withdrawal symptoms in chronic users and animal models" - it does NOT produce acute memory impairment NOR dependence/withdrawal symptoms in chronic users.

    • 1 year ago
  • GodsnLiberals
  • bdub4u
    • +2
      bdub4u  

    • godsinliberals, you think all those people in the 60's that were protesting and affecting actual change, not vietnam so much as civil rights and a variety of other issues, were just mindless dope fiends? NO, they smoked pot, together as a communal ritual, and had deep thoughts/conversations about the kind of relationship we want with authority. Thinking deeply and more conclusively/proactively about what role we want the state to play in our lives.
      Don't you think that if pot only made people into slavish drones that the dark authority of this world would want it legal so we would all be high and blindly submit???
      They know that if we are all sharing in rituals like smoking cannibus/enjoying it's many products, we will learn more about hemp and all it has to offer us. We will become more self sufficient with more natural ways of living than depending on horrible corporate processed food/clothing/life. They know that we will organize more, and separate ourselves from each other less.
      These dark powers would rather us all be scared in our living rooms, scared of all the DOPE FIENDS and DRUG DEALERS on every corner, than enjoying 5000 year old natural herbs that enhance one's sense of being and break down the walls preventing communities from uniting together as one.

    • 1 year ago
  • irie_ojo
    • 0
      irie_ojo  
    • bdub4u:

      great comment...
      once again i see "godsnidiots" posted a comment in response to me but i guess he/she missed your comment...or is it that he/she has no legitimate argument... thanks for clearing up that cannabis users are NOT "weak minded"

      but the sad fact is "godsnidiots" will never listen...i guess he/she has a "strong mind" LOL

    • 1 year ago
  • satan_lucifer
  • StephenJohnson
    • +6
      StephenJohnson  
    • Image

    • US Government's Patent

      United States Patent 6,630,507
      Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)

      "Cannabinoids as antioxidants and neuroprotectants"

      "The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia."

      http://www.patentstorm.us/patents/6630507.html

    • 1 year ago
  • irie_ojo
    • +1
      irie_ojo  

    • for everyone on this post:

      while i would love to respond to "godsnidiots" but he/she continues with the weak minded comments. i have try to boycott "godsnidiots" when the "weak minded" comments are use....

      as most know cannabis is non-addictive "dependence/withdrawal symptoms in chronic users and animal models" are habitual not dependent.... once a "chronic" user stops smoking, there is no illness from the withdrawal process.

    • 1 year ago
  • GodsnLiberals
    • -2
      GodsnLiberals  
    • irie_ojo:

      hahahaha denial...ohhh okay...you will see only what you want to see...

      and of course you have to resort to personal attack..nice...shows that you are incapable to engage in a debate..

      you are contradicting the very study that you seem to be praising...

      stop smoking DOPE..

    • 1 year ago
  • julimc
    • 0
      julimc  
    • GodsnLiberals:

      "hahahaha denial...ohhh okay...you will see only what you want to see..."

      From the comments I've seen you post, you seem to do the same thing.
      Cannabis is the devil right. And there can be no middle ground.

    • 1 year ago
  • irie_ojo
    • 0
      irie_ojo  
    • GodsnLiberals:

      i love to debate and am glad when people of the opposite side voice their opinion. but you have no argument and you will never listen to reason.
      and where is the personal attack?

      i just am tired of you always using the phrase "weak minded." when you have a legitimate argument i respond.

      and the only thing that i praised on this article was the fact that it stated that cannabis does have benefits for your body other then just the high.

      the only denial here is on your side....... denial of ignorance. (that is more of a personal attack, not boycotting you when you use "weak minded")

      and i dont smoke "dope"

    • 1 year ago
  • Capicuaman
    • +2
      Capicuaman  

    • Forget the neurological implications, cannabis smokers are just more (and I hate to use the Cliché) "opend minded" and in my experience make better friends. Cannabis haters are the trolls of real life.

    • 1 year ago
  • GodsnLiberals
    • -6
      GodsnLiberals  

    • but then i guess most DOPE FIENDS here have the same brain size of a rat...so it does apply...

      ITS COMMON FOR DOPE SMOKERS TO GET ALL GIIDDY of things they dont understand..all you have to do is put glitter into it..hence those liberal morons in hollywood making millions out of these idiots..

    • 1 year ago
  • StephenJohnson
  • Conniepae
  • vicgal
  • Vierotchka
  • GodsnLiberals
    • -4
      GodsnLiberals  

    • okay to all those DOPE FIENDS turn scientists here in this room,,

      can someone please explain what this means.."It has been shown that acute, high doses of CB1 agonists or cannabinoids produced anxiety-like effects in rats (44–49) or depression-like effects in mice (50, 51). We observed here that chronic administration of high, but not low, doses of HU210 exerts anxiolytic- and antidepressant-like effects. To make things more complicated, acute, low doses of cannabinoids have been found to induce anxiolytic-like effects in rodents (44, 49, 52, 53). These complicated effects of high and low doses of acute and chronic exposure to cannabinoids may explain the seemingly conflicting results observed in clinical studies regarding the effects of cannabinoid on anxiety and depression (3, 4, 10)..."

    • 1 year ago
  • tbowman131
  • Vierotchka
  • GodsnLiberals
  • Conniepae
    • +1
      Conniepae  
    • GodsnLiberals:

      ooooo, 'high on dope'. You're so mean. Are you trying to be insulting? Just asking.... what's your point? You seem to stutter, but I don't understand what you are trying to say? lol

    • 1 year ago
  • Vierotchka
  • Conniepae
    • +1
      Conniepae  

    • If I were a betting woman, I would bet they ignore it and just 'move along'. If facts don't get reported, are they really facts? Yes!

      Fortunately, there are sites like current and others who share facts, enabling more and more Americans to come out of the closet to join the conversation.

      Some say, there are more important things going on. The 'war on cannabis', on American soil, is not important enough to be discussed. I strongly disagree. These facts should not be ignored. A war on American soil 'is' important. How can the war end if we don't start some diplomacy? It's time to have the conversation and end this war on our own shores.

    • 1 year ago
  • irie_ojo
    • 0
      irie_ojo  

    • i bet we wont hear anything from any of the " cannabis -haters" on current....

      what will they say"yeah it helps your brain but it also makes you weak minded"LOL

    • 1 year ago
  • GodsnLiberals
    • -4
      GodsnLiberals  
    • irie_ojo:

      okay lets read a small snippet out of that article..

      "Cannabinoids appear to be able to modulate pain, nausea, vomiting, epilepsy, ischemic stroke, cerebral trauma, multiple sclerosis, tumors, and other disorders in humans and/or animals (1–7). However, marijuana has been the most commonly used illicit drug in developed countries, producing acute memory impairment and dependence/withdrawal symptoms in chronic users and animal models>>"

      okay how do you comprehend ...."However, marijuana has been the most commonly used illicit drug in developed countries, producing acute memory impairment and dependence/withdrawal symptoms in chronic users and animal models>>"
      ???????????????????????????????

      SECOND

      do you really have OR HOW MANY % OF THOSE PRO-DOPE people here are really sick to warrant thier use.........????

      are you sick or just a fiend??????

      PEOPLE WHO SMOKES DOPE TO GET BY IN LIFE ARE WEAK MINDED MORONS...

      AGAIN,,,

      PEOPLE WHO SMOKES DOPE TO GET BY IN LIFE ARE WEAK MINDED MORONS...

    • 1 year ago
  • Conniepae
    • +1
      Conniepae  
    • GodsnLiberals:

      Here are a few quotes from 'weak minded' Americans who have been willing to talk about it.

      "The war on drugs has been an utter failure. We need to rethink and decriminalize our nation's marijuana laws." -Barack Obama, January 2004

      "The illegality of cannabis is outrageous, an impediment to full utilization of a drug which helps produce the serenity and insight, sensitivity and fellowship so desperately needed in this increasingly mad and dangerous world." - Carl Sagan, renown scientist, astronomer, astrochemist, author and TV host

      "Why use up the forests which were centuries in the making and the mines which required ages to lay down, if we can get the equivalent of forest and mineral products in the annual growth of the hemp fields?" - Henry Ford, whose first Model-T was constructed from hemp fibers and built to run on hemp gasoline

      "Prohibition... goes beyond the bound of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded" -Abraham Lincoln

      "The prestige of government has undoubtedly been lowered considerably by the prohibition law. For nothing is more destructive of respect for the government and the law of the land than passing laws which cannot be enforced. It is an open secret that the dangerous increase of crime in this country is closely connected with this." - Albert Einstein quote on Hemp

    • 1 year ago
  • buddahla
    • +1
      buddahla  
    • GodsnLiberals:

      can we take this in a different direction...I'd like to know what substances that are legal you'd also like to see outlawed and the users deemed weak criminals. Are you also going to stand for a call for us to prohibit alcohol once again, tobacco? I'm asking this honestly, what's your opinion on OTHER substances which are legal. Should beer drinkers be put in prison? Should bar owners be charged with federal crimes for abetting society's deliquencies? By keeping marijuana illegal, this is the only logical take I can assume from your stance, that all other mind-altering substances must also be made worthy of incarceration. your thoughts...

    • 1 year ago
  • medHead
  • onechance
  • GodsnLiberals
  • onechance
  • onechance
  • Capicuaman
  • GodsnLiberals
  • Vierotchka
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