Green | August 22, 2008 | 1 comment

Scientists unravel molecule that protects from bacteria and other pathogens

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Scientists at UT Southwestern Medical Center have found a potential new way to stop the bacteria that cause gastroenteritis, tularemia and severe diarrhea from making people sick. The researchers found that the molecule LED209 interferes with the biochemical signals that cause bacteria in our bodies to release toxins. "What we have here is a completely novel approach to combating illness," said Dr. Vanessa Sperandio, associate professor of microbiology and biochemistry at UT Southwestern and senior author of a study available online today and in a future issue of Science. Though many antimicrobial drugs are already available, new ones are needed to combat the increasing microbial resistance to antibiotics. In addition, treating some bacterial infections with conventional antibiotics can cause the release of more toxins and may worsen disease outcome.
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