Green | October 20, 2008 | 15 comments

Alzheimer's and fatty acids

Image
oblivious
Controlling the level of a fatty acid in the brain could help treat Alzheimer's disease, an American study has suggested.

Tests on mice showed that reducing excess levels of the acid lessened animals' memory problems and behavioural changes.

Writing in Nature Neuroscience, the team said fatty acid levels could be controlled through diet or drugs.

A UK Alzheimer's expert called the work "robust and exciting".

There are currently 700,000 people living with dementia in the UK, but that number is forecast to double within a generation.

Over-stimulation

Scientists from Gladstone Institute of Neurological Disease and the University of California looked at fatty acids in the brains of normal mice and compared them with those in mice genetically engineered to have an Alzheimer's-like condition.

They identified raised levels of a fatty acid called arachidonic acid in the brains of the Alzheimer's mice.

Its release is controlled by the PLA2 enzyme.

The scientists again used genetic engineering to lower PLA2 levels in the animals, and found that even a partial reduction halted memory deterioration and other impairments.

Dr Rene Sanchez-Mejia, who worked on the study, said: "The most striking change we discovered in the Alzheimer's mice was an increase in arachidonic acid and related metabolites [products] in the hippocampus, a memory centre that is affected early and severely by Alzheimer's disease."

He suggested too much arachidonic acid might over-stimulate brain cells, and that lowering levels allowed them to function normally.

Dr Lennart Mucke, who led the research, added: "In general, fatty acid levels can be regulated by diet or drugs.

"Our results have important therapeutic implications because they suggest that inhibition of PLA2 activity might help prevent neurological impairments in Alzheimer's disease.

"But a lot more work needs to be done before this novel therapeutic strategy can be tested on humans."

-A lot more to do, but we're getting there.
  1. groups:
    Green,   Culture,   Earth and Science,   Health,   1 more
  2. tags:
    Culture Green Earth and Science Health 1 more
  3.     
    |

15 comments // Alzheimer's and fatty acids

  • lizzie1000
    • 0
      lizzie1000  
    • Absolutely right. It comes down to power and greed!

      The epidemic of dementia, especially in the under 70s is directly related to the rise in Western diseases. We did not evolve needing drugs, they are a direct result of the life styles we lead.

      However it is not in the interests of a Western doctor or drug company to have a healthy population. The only guaranteed growth in the West comes from the "healthcare" industry.

      We have to take responsibility for our health and reject "medical solutions"

    • 3 years ago
  • CarolynGillis
    • 0
      CarolynGillis  
    • Image
    • Link on this subject..we are being fooled by the Pharmaceutical companies Media the FDA and the medical system.

      Here is a Harvard study group.

      Another resource for brain health..I think was at Harvard also...his name I beleive was Andrew Heibben.MD..he put out studies many years ago about Omega 3 and brain health and depression..gets no air time..our reality is shaped by these horrible ads...buy more drugs...got to go!

      The media is funded by these immoral Direct to Consumer Drug advertising. This is banned in other countries..keeps getting voted right down here.

      Nutraceuticals are the new direction for preventive health care..we need to get to it under Obama right away.

    • 3 years ago
  • jahbini
  • lizzie1000
    • 0
      lizzie1000  
    • Dementia, senile dementia was, twenty years ago sufficiently rare to warrant a brain biopsy

      Nowadays 50% of 85 year olds have dementia. It has not been around since ancient history - very few modern diseases were seen prior to the twentieth century

      The first heart attack was recorded in 1906

      Do you think that Marshmallows are herbs or sweets?? are you just trying to be clever / patronising, or do you just enjoy eating processed junk food?

      Personally I would rather people ignored postings than were gratuitously offensive

    • 3 years ago
  • jahbini
    • 0
      jahbini  
    • Lizzie:
      "Dementia was unheard of twenty years ago"

      That statement is 100% wrong. Senile dementia is the 'old' name for alzheimers. It has been around since recorded history.

      If you say things like that, the effect is that every other statement in your postings is ignored (or worse, make people doubt everything you say).

      And BTW, Marshmallow is not a tree it is a herb, and according to wikipedia: "Early Romans and Greeks ate the flowers of the marsh mallow plant originally as preventative medicine"

      Do your research, check your facts, and edit your thoughts: it is a good use of your brain, and you may sway people with your words.

    • 3 years ago
  • lizzie1000
    • 0
      lizzie1000  
    • The researchers have found that feeding rats too many omega 6 fatty acids - the ones in biscuits and processed fat based food causes dementia
      The important omega fatty acids are omega 3 fatty acids
      this is part of the food industry's attempt to discredit healthy products - by confusion and misinformation

      TRUTH
      Dementia was unheard of twenty years ago, the incidence of dementia is rising exponentially, not because we are living longer but because we are less healthy

      Good research shows that a healthy diet, a healthy mind, exercise and social networks protect against dementia

      However with dementia drugs costing £1,000 or more a year, who apart from the individuals concerned wants thta information to get out.

      Dementia is just another thing to scare people with, scared people comfort eat, comfort eating leads to a range of modern diseases, including dementia

      If it wasn't around 10,000 years ago, you probably shouldn't be eating it! have you seen a marshmallow tree??

      Eat natural, run around lots, make friends and use your brain!!

      Lx

    • 3 years ago
  • oblivious
    • 0
      oblivious  
    • There are so many components to Alzheimer's that it may be a while before we know how to treat it effectively. Its even referred to as "possible Alzheimer's" because the only way to actually diagnose it is to examine the brain, postmortem. The more we learn about it, the more we can hopefully find out about the mechanisms, and hopefully that will lead to a treatment, since disease projections are showing that it can affect up to 8 million people by 2030.

    • 3 years ago
  • taintedview
  • Stealthcy
    • 0
      Stealthcy  
    • I've seen over 45 different articles on ways to help with Alzheimer's, so when are they going to find something that works because it seems they're just going in circles with these studies...

    • 3 years ago
  • taintedview
    • 0
      taintedview  
    • i get the impression that these people have no idea what they are doing. There have been posts saying the probelem lies in anything ranging from Mad cow infection to vitamin D difficiency. All i want to hear is when they actually help a person with one of these treatments, not probable false hope.

    • 3 years ago
  • kirru
    • 0
      kirru  
    • ahhha.......I was about to post this news item and I saw this just now....thats fine, its a very interesting and useful information for everyone who is in need of it..

    • 3 years ago
  • animalia_libero
  • oblivious
more from Green:

top videos