Politics | August 18, 2008 | 61 comments

Medical marijuana: Can't smoke it, but FDA approved scientifically regulated THC

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arcticspirit
Medical marijuana already exists. It's called Marinol.

The FDA has not approved smoking marijuana for medicinal purposes, but has approved the active ingredient-THC-in the form of scientifically regulated Marinol.

A pharmaceutical product, Marinol, is widely available through prescription. It comes in the form of a pill and is also being studied by researchers for suitability via other delivery methods, such as an inhaler or patch. The active ingredient of Marinol is synthetic THC, which has been found to relieve the nausea and vomiting associated with chemotherapy for cancer patients and to assist with loss of appetite with AIDS patients.

Unlike smoked marijuana--which contains more than 400 different chemicals, including most of the hazardous chemicals found in tobacco smoke-Marinol has been studied and approved by the medical community and the Food and Drug Administration (FDA), the nation's watchdog over unsafe and harmful food and drug products. Since the passage of the 1906 Pure Food and Drug Act, any drug that is marketed in the United States must undergo rigorous scientific testing. The approval process mandated by this act ensures that claims of safety and therapeutic value are supported by clinical evidence and keeps unsafe, ineffective and dangerous drugs off the market.

There are no FDA-approved medications that are smoked. For one thing, smoking is generally a poor way to deliver medicine. It is difficult to administer safe, regulated dosages of medicines in smoked form. Secondly, the harmful chemicals and carcinogens that are byproducts of smoking create entirely new health problems. There are four times the level of tar in a marijuana cigarette, for example, than in a tobacco cigarette

The DEA recognizes the importance of listening to science. That's why the DEA has registered seven research initiatives to continue researching the effects of smoked marijuana as medicine. For example, under one program established by the State of California, researchers are studying the potential use of marijuana and its ingredients on conditions such as multiple sclerosis and pain. At this time, however, neither the medical community nor the scientific community has found sufficient data to conclude that smoked marijuana is the best approach to dealing with these important medical issues.

The most comprehensive, scientifically rigorous review of studies of smoked marijuana was conducted by the Institute of Medicine, an organization chartered by the National Academy of Sciences. In a report released in 1999, the Institute did not recommend the use of smoked marijuana, but did conclude that active ingredients in marijuana could be isolated and developed into a variety of pharmaceuticals, such as Marinol.

In the meantime, the DEA is working with pain management groups, such as Last Acts, to make sure that those who need access to safe, effective pain medication can get the best medication available.
  1. groups:
    Politics,   WTF
  2. tags:
    Politics WTF Cannabis Medicine 14 more
  3. credits:
    arcticspirit Understands medical THC already exhists!, Angel4truth supports medical THC in pill form
  4.     
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61 comments // Medical marijuana: Can't smoke it, but FDA approved scientifically regulated THC

  • sativa
  • coinscience
    • 0
      coinscience  
    • its not youre fault just keep on trying to make youre life the happyest place you can make it!!!
      Dont give in and you will find eternal joy somewere. Just keep on trying!!!!!:D

    • 2 years ago
  • sativa
    • 0
      sativa  
    • im sorry dude!!!! ive been half reading whats there after losing my temper with the rest of the world today when i got messed about at the hospital this afternoon.
      and dont cuss your own life mate believe me, theres gonna be millions of people that will see you every different day of your life and wish they had something you have.
      if i didnt have my daughter and i couldnt have my greens when ambers not with me i would have ended it a long time ago but amber gave me a massive boost with something to be proud of and made me lift my chin and start to grin and get my head back together.
      trust me, you have something noone else has and half of em would love mate even if you dont know what it is yet!
      but as i said im sorry im in a really bad mood and probably shouldnt be dropping comments on chatboards but gettng no scan wound me up a long way and i kinda got unleashed on you! :)

    • 2 years ago
  • coinscience
  • coinscience
  • sativa
    • 0
      sativa  
    • and as far as short term pain relief goes, search again and look for things like arthritis and bone density problems brought on by medication prescribed for other health problems, or all of the other stuff simply caused by short term illness and after effects that aint big enough to use 'cannabis as a cure'
      its like a moaning ex, you cant cure everything mate!

    • 2 years ago
  • sativa
    • 0
      sativa  
    • for starters who said i cant stand life you sap?
      i cant do anything about whats been happening thats pretty much wrecked my life mate so ill just carry on rolling.
      cant drive, cant work cant fucking grow up cause im stuck as the 21 year old that found out he was stuck in a barell and the lid wont come off.
      ive got a 10 year old daughter thats been phoning ambulances for me since she was 3 years old and a wife im no longer with cause of the pressure it all caused after finding out it wont come out and was malignant 3 months after my daughter was born.
      life, its shit, when your not smiling and thats not about being stoned. its about enjoying what you have got instead of frowning about what you want.
      nobody can do anything for me apart from me basically, so ill do it my way and with a smile and a nice easy lean towards enjoying the joint i just rolled knowing that the thc/cbd/cbn receptors that are sat on top of my tumor are taking control of everything and calming it all down a lot better than any medication ive ever been prescribed.
      im shouting my mouth off in a bad way i know but thats after trying to get a scan done today and having a fit on the scanners table 3 times and ending up being told "you will have to come back tomorrow as we finish at 3".
      see how much help i get?!!!!!!!!!!!!!!!!
      just roll, smile and shout fuck it.
      its all i can do, but the worst side of that?
      its more than a doctor, a therapist or a surgeon can do for me, yet still its illegal.
      keep smiling dude, it all hurts less.
      thats the pain killer, nothing more, nothing less.
      SMILE.

    • 2 years ago
  • coinscience
  • sativa
    • 0
      sativa  
    • yes it does mate.
      so please go out there and find the cure for the malignant left temporal oligondendroglioma they cant do anything about thats sat in my head, and untill you do, ill leave it to thc, cbd and cbn to take care of and stop my fits the way they have been. thc on its own does not work.
      i was told in 97 i would be dead by 02.
      i aint got a headache and im not in a bad mood.
      ive got cancer.
      I cant have chemotherapy, i cant have radiotherapy and they cant do any surgery.
      im 32, ive been smoking weed for 18 years and i found out i had the tumour when i stopped smoking it for 6 months and my fits started and my brain scan was done.
      i know it brings you life mate.
      ITS WHY IM NOT DEAD

    • 2 years ago
  • coinscience
  • coinscience
    • 0
      coinscience  
    • real weed always better but not as standerdised but for people with major illness they need a cure!!! not a temporary pain relief but weed is still a good answer for many things like makeing people happy and chilling out when they have problems!!

    • 2 years ago
  • sativa
    • 0
      sativa  
    • thc on its own wont work
      Take the sativex and spray it on a joint and you get more than thc, why?, because of the cbd and cbn levels in the straight foward buds that do different things to different people.
      Your getting high on THC and stoned on the CBD/CBN, mix the three and and the difference is massive. Get the levels right and your head starts working.
      Search cannabis and epilepsy and you will see, thc works but a lot better with cbd applied at the same time, same as cbd wont work without thc.
      A straight regulated dose of thc alone in a medicinal situation aint doing a lot for anybody.
      So in english, buy your weed, spray the joint with sativex if you get a bottle and feel a lot better about it.

    • 2 years ago
  • coinscience
  • coinscience
  • coinscience
  • covelogibbs
  • sickinjersey
    • 0
      sickinjersey  
    • I am prescribed marinol, and it does not work the same as ingesting marijuana.it just feels like another pill is in my body and they don't digest very well.

    • 3 years ago
  • sativa
    • 0
      sativa  
    • its all well and good that a synthetic thc may work but when its simply known that thc left as it is can and will do the treatment how has it not been licensed to treat with by now?
      i have a brain tumour that causes massive fits and times when i dont have a clue what i did or what happened, yet using cannabis as an illegal medication i manage to handle any fits as an 'absence', your a little but lost in the head for a few seconds basically, rather than hitting the floor and going to hospital everytime.
      if you search for it, and excuse me for not dropping a link, you will find reports of thc against brain tumours and the results from testing against marinol with the results from the thc testing massively outweighing those from marinol, total removal of some of the tumours without any surgery at all.
      if the marinol can be improved and make this treatment work then there is no question of me using what woud hopefully become a prescribed treatment for the tumour. but when the better and more succesfull treatment already exists and is called thc, why research a synthetic version at the massive expense it comes with??????

    • 3 years ago
  • covelogibbs
    • 0
      covelogibbs  
    • Image
    • "Sativex is distinct from all other pharmaceutically produced cannabinoids currently available because it is derived from botanical material, rather than a solely synthetic process."

      Marinol, although it will get you plenty "high," has been reported by patients as not being as effective as the real thing (in killing pain and nausea). Sativex sounds like it would be a much better option.

      Smoking marijuana is not the best way to administer the drug, although it may be the easiest. As mentioned above, a vaporizer, or ingesting would be much better.

      What the big pharmaceutical companies don't want people to know is that you can enjoy the pain relieving benefits of marijuana without getting high. In fact, depending on what kind of pain one has, eating the large "sun" leaves of the marijuana plant can be more effective than smoking the flowers. Also, there are varieties of cannabis with less THC, but more of the beneficial Cannabinoids. Good luck trying to get the better pain reliving cannabis, with most growers going for the bigger "high."

      The reasons the real science is not getting done with cannabis are numerous. It could replace so many products on pharmacy shelves, and with little to no side effects, that there is way too much money involved in keeping it illegal and demonized. When you factor in the industrial uses of cannabis, such as food, fuel, clothing, paper, plastic, etc., it's such a threat to the establishment, that it's no surprise it's illegal to grow even though the industrial varieties won't get you "high."

      The fact that you, arcticspirit and Angel4truth, have put so much time and energy into this thread shows me that you care about the subject and are thinking about it, but I believe there is a lot you could still learn about the issue (me too!).

      Comparing marijuana to alcohol and tobacco, from a medical/public health perspective, seems like an insult to cannabis and may show a lack of understanding of the consequences of using these substances. Thank you and please keep seeking truth and knowledge.

    • 3 years ago
  • Angel4truth
    • 0
      Angel4truth  
    • I am just adding a note. Sorry I was absent and did not answer questions addressed to me last week.

      I did try to answer everyone that asked me questions. If I missed you, please send a message and I'lll get it.

      I realize what I say many don't agree with. But I hope that some see medical vs recreational pot in a new way.

      And if you want to get high on pot, that's your deal. If you want it leagal, don't veil it under medical use, contact your congressmen, give petitions or speak in front of congress, and see if they will agree. tell them you want your right to get high.

      with the counterculture of drugs they might change laws. who knows?

      will there be consequences, possibly more than you would bargain for. but at least you'll be high and won't care. and many people routinely get high illegally, they won't care either.

      responsible use of pot? wow. what is the defination of that? Getting high only after 5pm? only on weekends? Only a few times a day? A few times a week? Everyone will have a different take on it.

      Should you do it around kids? I think not. Reason? second hand smoke. and all the other moral reasons. just because you want it doesn't mean it's good for everyone, including children.

      ok the horse has been beaten pretty hard here.

    • 3 years ago
  • cocheezy
  • damnneargenius
    • 0
      damnneargenius  
    • The meaning of life is happiness. If you weigh the short-term and long-term pros and cons of something, and it can bring you toward leading a more enjoyable life, more power to you.

      All people are different. All circumstances are different. The application of any substance into a situation should be gauged on its effectiveness towards a desired outcome. As long as that desired outcome is not criminally harmful towards others or unreasonably self-destructive, then there should be no reason to denounce it.

      Our society if FAR too full of blanket labels, stereotypes, and "expert" opinions from people on the outside who ironically have little first hand knowledge of what they speak. Scientists are good at being scientists, that doesn't necessarily make them exceptional psychiatrists or philosophers. Since their studies are quite often funded by special interests, what do you think the studies are going to conclude? Probably whatever the person funding them wants them to conclude.

      I say take everything in context. If you're suffering from cancer or pain, feel free to take whatever you want to make what's left of your life as tolerable as possible. If you're not suffering some serious medical ailment, then marijuana still isn't much worse than alcohol or tobacco, and, as long as you use it responsibly, I don't see what all the fuss is about.

      It should be licensed, taxed, and regulated to acceptable use along the same lines as alcohol if you ask me. The behavior alcohol induces is far more dangerous than marijuana, which is the obvious benchmark of our society.

      I say, use your own best judgment and apply that to yourself and only yourself. The pros and cons should simply be estimated on a case-by-case basis.

    • 3 years ago
  • Angel4truth
    • 0
      Angel4truth  
    • damnneargenius:

      Thanks, I agree with all you wrote, but one thing.

      Just because you are seriously ill, self medication is usually self defeating. and if you are that sick, chances are you are on some sort of medical "cocktail" and you don't need to add additional anything.

      If you have pain issues and your doctor doesn't help, there is a law against that. He/she has to refer you to another doctor at least.

      Sadly most people who are spending half their income on meds don't have the cash to take doctors to court for under medication or irresponsible acts.

      I know someone who had been treated with morphine for like 8 years. She had to change doctors. Her doctor had a "problem" with narcotic medicines and took her off cold turkey.

      She was in agony for months and could not and still cannot function.

      Can she go to court, no. No money.

      Was the doctor considered irresponsible, I thinkyes, as he didn't put her under medical supervision beyond her going to the ER because withdrawal from narcotics "IS NOT FATAL".

      I disagree, she nearly commited suicide.

      But did she turn to illegal meds, not yet.
      Will she? I don't know. Maybe.
      Will it be good for her if she does? actually it could kill her.

      Very sad.

      Would making pot legal help her. She would probably take something that did more for seratonin, and that would not be weed. E has been known to kill
      just because it's different and the pharmacy can't say oh .. it's fine if you take e with your med cocktail.

      yeah it's a horrible situation. Especially when patients cannot take legal protection from irresponsible doctors.

      but e, weed, etc. is not the answer.

    • 3 years ago
  • asherp
  • Angel4truth
    • 0
      Angel4truth  
    • asherp:

      False.
      Would you like to have to rape the rain forests for rare chemicals and get side effects that might harm you because the government doesn't want you to have plants? Most don't consider that.
      Our meds are often properties of plants and doing it chemically allows medical use without destroying the environment and allows a doctor to treat someone knowing what they are getting.

      Sure weed can be grown in excess. Big deal. That doesn't make it a safe medicine. Please. The Use more of that brain or is it gone?

      I would think the FDA doesn't approve it for several reasons and none is to screw the public. That's stupid. OMG I can't believe you even thought that.

      read a spirt's explanations on medical usage. You may understand.

      And she is way more patient that i am. I think if you want legalization for the purposes of getting high, don't veil it in medical use.

      Say what you mean and go for it. If it's a good idea the public will allow congress to pass it.

      That's the point of my argument.

    • 3 years ago
  • brinna
    • 0
      brinna  
    • 6. Cannabis doesn't do terrible things to your body, in fact, quite the opposite. A study done in the 1980's in Jamaica by Dr. Melanie Dreher showed that babies born to cannabis users tested BETTER on 30 day evaluations than babies born to non-users. After 5 years of age these cannabis kids were doing just as fine as cannabis deprived kids. Bet you haven't heard about that study, have you. That's because of the Government's disinformation campaign. Here is a link to a lecture on the study: http://vids.myspace.com/index.cfm?fuseaction=vids.individual&videoid=3931312...

      7. If cannabis use caused heart attacks there would be a lot more dead people around. Viagra, however, does cause heart attacks. mmmm .... I don't hear a lot of calls for banning Viagra. I wonder why?

      8. A recent large study by Dr. Donald Tashkin of NIDA demonstrated that even long term chronic users of smoked cannabis had NO elevated risk of lung cancer. They conjecture that that is due to the anti-cancer activities of cannabinoids. Put that in your pipe and smoke it. But don't put tobacco in your pipe -- that will kill you.

      9. Angel, as a mouthpiece for the government dogma, you seem inordinately concerned with THC. Actually, that is the problem with synthesized drugs, they are taken out of context. They are manipulated so they may be patented, which means that the natural molecular structure is altered for purely commercial reasons. Think "birth control pills": synthetic progesterone offers no protection against breast cancer, but it was put in birth control pills because it was patentable. And women got breast cancer from it. Yes, I really trust drug companies to have my best interests at heart. And our dear government is in bed with them.

    • 3 years ago
  • brinna
    • 0
      brinna  
    • OK, this is a point by point response to angel4truth.

      1. the ban on cannabis has caused: drug cartels, criminalization of youth, sales to minors, restrictions on research, oppression of minorities and other undesirable groups. It has done nothing to reduce cannabis use.

      2. There are many "legal" medications that contain the warning: "Do not drive or operate heavy machinery." Should they be banned?

      3. People think they are safer when they take a pill, because the amount is regulated. In fact, the regulated amounts are often too strong for the elderly, and women or people with small frames. So where is the safety in pills?

      3. Stronger cannabis is better because you use less. People titrate effectively when smoking, though it is less easy to do when ingesting. Never-the-less, it is impossible to overdose on cannabis. You will simply fall asleep (granted you don't want to be driving at the time -- but you don't want to be driving on Nyquil either).

      4. What, I ask you, is the problem with making cannabis legal for responsible adults? The government is so afraid of medical cannabis because they rightly feel that when people realize how benign it really is, they will insist that we stop wasting 30 billion a year on its eradication.

      5. People who use cannabis recreationally do not "crawl out of the woodwork" like worms. They are not slackers nor pot heads, nor losers, nor sub-human, nor scary, nor communists, nor hippies. They are regular folks just like you, angel. Only they do not feel the need to marginalize those who disagree with them.

    • 3 years ago
  • Angel4truth
    • 0
      Angel4truth  
    • brinna:

      Hi Brinna,
      That was an interesting thing you came up with.
      First of all, I used common sense and medical evidence, not some sort of brainwashing.

      The conversation is about medical use of THC to treat what it is intended. but yes, I inserted comments about why people come out in groves to legalize it, and not for medical reasons probably. Yeah, they do come out from seemingly the woodwork. I am sorry if you don't like it. But post about pot, see what happens?

      A spirit, has introduced the element of expanding the study for pain control, but I agree with many here that the drug they are using probably needs different elements.

      I think a spirit covered the importance of maintaining the ability for the doctor to single out the medicine, properties of the weed, etc. for each person. Especially for people with medical conditions.

      I still disagree strongly that smoking anything could ever be good for something. Medical studies confirm that. And pot is way worse than cigarettes.

      Do I think every medicine with warning should be banned, no. The warnings are there for a purpose.

      Do I think that weed is the root of all evils, I have no opinion on that. I have screen people who's lives seem to freeze without progress after developing a "habit" of being high most of the time.

      I imagine that doing illegal drug deals so increase stress.

      As far as the youth is concerned, the same would go if it was regulated. It would most likely be for those over 21. If they wanted it, it would go thru the same channels. Think. Youth using it totally screws up their school stuff and probably not be as sucessful as others that didn't do pot. Memory etc. is vastly effected, hard to do college level stuff when your brain cells are crap. It affects the frontal lobe, maybe others. Not good.

      That alone sucks, but you say people are productive. Ok.

      About the legalization of weed for the general population, with extensive regulation, this is a good idea, people routinely get lung cancer (yes one doctor out of many who have studied say it's not gonna happen. yeah.) from cigarettes,, people destroy their livers and their lives with alcohol. I guess people should have the choice to destroy their lives with pot.

      Would be interesting if insurance companies would continue to pay for weed-related conditions, i.e. cancer (oh yeah the majority of doctors are wrong because one said it's not true..), drug abuse, etc. Currently they do cover substance abuse because that is less expensive in the long run than to treat the consequences of said abuse. We do know that rates are higher for smokers. of course that may tatke both out of the system, who knows?

      As for a pill not being safe as a plant.. that is laughable. When taking meds, the doctor usually starts with a baby dose and increases it slowly. Have you been to a doctor with a medical condition? If so you would know this.
      Adjustments to the med are easier as he/she would know exactly what and how much the patient is using. That excuse is full of holes.

      Natural does not equal safe.

      FDA is there for a purpose.

      Hope I addressed your problems with MEDICAL thc.

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • (continued from above post by me. thanks for reading)

      That would be your decision. I totally respect that.

      Personally from the nightmare stories that I have hard from people taking "natural" remedies for different pain diseases alone or with medicines, I vote for the FDA researched specifically dosed and consistent quality product.

      I have created in 1994, and it is still very active, an online support group for people with chronic pain conditions. My buddy Dougal, coded it in perl and I did the html for the information website that went with it on different pain conditions.. all in word pad. Geez that was so long ago!

      But, over the years many people have found themselves in the ER or have had some pretty bad stuff happen just due to the lack of regulation, computability and quality of the "natural " products.

      My point is natural does not equal safe.

      We see this argument come up every year when new people come around. It's interesting.

      I tell people it's a personal choice.

      One girl told me she uses "e" to control her pain. I know why she did it, but didn't agree with it due to the same reason, lack or regulated doses & quality. But "e" gives a huge seratonin boost and that therefore reduces the pain, exhaustion and depression of people with chronic pain syndromes.

      Hey thanks for reading all.
      Have a good one :)

    • 3 years ago
  • covelogibbs
  • arcticspirit
    • 0
      arcticspirit  
    • First of all..
      THANK YOU for reading that long, long discussion about medical use of THC. I know that took up time, and I truly appreciate that you did.

      I saw many posts about the natural product being better than the approved synthetic THC that is available and working for the ailments it was designed to treat. Key HERE is what it is designed to treat, I think. They did isolate THC 9 and THC 11 during the process. Patients with AIDS & chemo did really well. Not much as been tested with chronic pain issues.
      There are 400+ other chemicals in plants, depending on what you have, and the presence of what you have can vary a bit. Many of the doctors do not suggest having all those other ingredients, it's just too much of a risk for a chronically ill patient. Especially one that would be on long term use.

      Long term use, I am thinking 20-30 or more years. So there is a bit more to consider in that case. Knowing that the person does not have the same immune or possibly cellular repair that a normal person has.

      The possibility of additional medicines being extracted and synthesized from the plant, in my humble opinion is rather high. Most of our medicines are derived from nature. Example Aspirin = white willow bark and buffering, stabilizing ingredients.. but how much bark do you eat to get the 500 mg for an extra str dose?

      (continued below....)

    • 3 years ago
  • dont112
  • edbr
  • arcticspirit
  • brinna
    • 0
      brinna  
    • THC is only one element of cannabis. It is not as effective as the full plant extract. THC's effect is mitigated by the other cannabinoids. Even the US Govt. holds a patent on the use of cannabinoids in the treatment and prevention of many diseases (patent #6,630,507). The real reason that it remains illegal is the pigheadedness of those in authority who do not want to look at what science shows, who blame cannabis for the very problems that have been created by its prohibition: crime wave, drug cartels, sales to youth. Clearly we must legalize, regulate and educate.

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • brinna:

      She can get to this when she is back, but I believe she wrote what she did on behalf of the medical conditions that THC is the chemical that is used to control.

      These conditions may be fewer? Than the ones isolating other parts of the plants. Indeed much of our medicine is derived from molecules of plant parts put together.

      My doctor told me that for my condition (I have several disabilities all are hard to manage.. so I have a 4 part medical team..) much of the other ingredients in the plant would make my condition worse, even if I didn't have an allergic reaction to the smoke. I can only speak of what has happened to me as a patient.

    • 3 years ago
  • brinna
    • 0
      brinna  
    • brinna:

      Hi Arctic spirit,
      cannabis is definitely not for everyone, and since you have an allergic reaction to the 2nd hand smoke, that is a good indication that for your body, it is not appropriate. I truly wish you the best of luck in dealing with your challenges, and know that your team has your best interests at heart.

      As for "angel4truth"'s diatribe, actually, the amount of disinformation in her (his?) is maddening. So perhaps I will take the time to answer point by point.

      All the best to you,
      Brinna

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • brinna:

      hI Brinna,
      This might have been bad timing on my part to post this when I did, but Angel left on vacation the day after is out of town until after the holiday.

      I doubt she meant any harm, but .. feel free to post back. That's what it's about. Write what you need to. I suspect there are pro's and cons on every subject. But keep in mind she was talking about it in the context of medical use compared to recreational. ?? um. She gets excited sometimes. uhh ? (smiles and shakes her head)

      With my medicines, each doctor wanted to contribute only one at a time for at least a month before adding another chemical. This can be a long long process with me. I'm on more than 14 different meds (this is after reducing them over the span of the last two years from over 20), taking them from 1 to 3 times a day, depending on the medicine. So for them, to have isolated parts of THC or anything else, is easier to prescribe.

      As more research is done, they may expand the drug to include other chemicals or keep them all separate so the doctor can have more control. (Just observation from me)

      I asked her to co-write because I only have pre-med, and experience of being very ill, (that changed everything for me when it comes to medicine & health care.) She knew more about everything else.

      I didn't want to tackle anything but the medical side really myself.

      Have a good one.
      a spirit

    • 3 years ago
  • edbr
    • 0
      edbr  
    • Image
    • the problem is that marinol contains only synthesized THC. there are thousands of other cannabinoids derived from marijuana that are part of its beneficial effects.

      the link above describes cannabidiol's and other cannabinoids' (individual components of marijuana) benefits as antioxidants and neuroprotectors.

      marinol is big-pharma's supposed solution to the medical marijuana issue. though, as usual, they're there to make a buck, not to extensively research and provide real, safe solutions.

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • edbr:

      Thank you for this link.
      I can very easily see your point of view. One shot treatment.

      From the information below, I want to add one thing on the medical side. That thought makes sense, until you apply it to a larger population of chronically ill patients.

      Often due to what a doctor is trying to treat, they cannot give a patient over 400 chemicals without unwanted side effects, or interaction with other medication. Keep in mind that chronically ill patients that could spend all their life on medication, often have differences in lymphatic, immune, circulatory and even cellular regeneration. Not to mention if someone has a psych issue they are dealing with... and the chemicals for that. AARGH!

      Also it's kinda hard to extract exactly how much of each chemical is present in any said amount of plant.

      For example... Aspirin came from white willow bark. It has stuff to buffer and stabilize it and is synthetic now. But if I chomp on white willow bark, how much do I need to eat to get an extra str dose (500?) And can it change from one tree to the next? Does the age of the tree or what section of the bark I eat matter... are there multi strains of white willows, and would I have the exact same dose from each one? No one OD's on white willow bark in this day either, but long term dosing that is inconsistent can hurt organs in a already sick person. I hope that makes sense.

      With me, we already know that I am allergic to some chemicals properties of the plant but perhaps I can get great benefits from other ingredients. My doctors always only change one medicine within a given month, that includes STR of medicne (between all of them) and I can see very clearly where doctors would want to have the compounds isolated so they could be used for many different conditions, and people like me.

      With as hard as the issue is to legalize this plant, I would think that companies are doing more than isolating the THC-9 and THC-11 that they have singled out for the nausea treatment (used for other stuff but made to help with that really.),

      Especially as you gave the link to and I will print below how different parts of the brain are affected by additional chemicals.

      And factor in that most discoveries in medicine are based from chemicals in plants.

      HERE's the breakdown. Yeah helps if you have med background. But basically it tells us that there are many chemicals in the plant that can help in different ways.

      My thoughts are still to isolate them for medical use to treat patients with a custom "cocktail".. but everyone has their own thoughts. The writer of the post I am responding to likes the one shot cures approach. I can respect that opinion as well.

      Enjoy:
      Here is the chemical breakdown they were talking about.

      1. A method of treating diseases caused by oxidative stress, comprising administering a therapeutically effective amount of a cannabinoid that has substantially no binding to the NMDA receptor to a subject who has a disease caused by oxidative stress.

      2. The method of claim 1, wherein the cannabinoid is nonpsychoactive.

      3. The method of claim 2, wherein the cannabinoid has a volume of distribution of 10 L/kg or more.

      (cont below)

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • edbr:

      (continued from my post above)

      4. The method of claim 1, wherein the cannabinoid is not an antagonist at the NMDA receptor.

      5. The method of claim 1, wherein the cannabinoid is:

      where R is H, substituted or unsubstituted alkyl, carboxyl, alkoxy, aryl, aryloxy, arylalkyl, halo or amino.

      6. The method of claim 5, wherein R is H, substituted or unsubstituted alkyl, carboxyl or alkoxy.

      7. The method of claim 2, wherein the cannabinoid is:

      where

      A is cyclohexyl, substituted or unsubstituted aryl, or
      but not a pinene;
      R1 is H, substituted or unsubstituted alkyl, or substituted or unsubstituted carboxyl;
      R2 is H, lower substituted or unsubstituted alkyl, or alkoxy;
      R3 is of H, lower substituted or unsubstituted alkyl, or substituted or unsubstituted carboxyl;
      R4 is H, hydroxyl, or lower substituted or unsubstituted alkyl; and
      R5 is H, hydroxyl, or lower substituted or unsubstituted alkyl.

      8. The method of claim 7, wherein

      R1 is lower alkyl, COOH or COCH3;
      R2 is unsubstituted C1-C5 alkyl, hydroxyl, methoxy or ethoxy;
      R3 is H, unsubstituted C1-C3 alkyl, or COCH3;
      R4 is hydroxyl, pentyl, heptyl, or diemthylheptyl; and
      R5 is hydroxyl or methyl.

      9. The method of claim 1, wherein the cannabinoid is:

      where R1, R2 and R3 are independently H, CH3, or COCH3.

      10. The method of claim 9, wherein the cannabinoid is:

      where:

      a) R1R2R3H;
      b) R1R3H, R2CH3;
      c) R1R2CH3, R3H;
      d) R1R2COCH3, R3H; or
      e) R1H, R2R3COCH3.

      11. The method of claim 2, wherein the cannabinoid is:

      where R19 is H, lower alkyl, lower alcohol, or carboxyl; R20 is H or OH; and R21-R25 are independently H or OH.

      12. The method of claim 11, wherein R19 is H, CH3, CH2OH, or COOH, and R20-R24 are independently H or OH.

      13. The method of claim 2, wherein the cannabinoid is:

      where R19 and R20 are H, and R26 is alkyl.

      14. The method of claim 10, wherein the cannabinoid is cannabidiol.

      15. A method of treating an ischemic or neurodegenerative disease in the central nervous system of a subject, comprising administering to the subject a therapeutically effective amount of a cannabinoid, where the cannabinoid is

      where R is H, substituted or unsubstituted alkyl, carboxyl, alkoxy, aryl, aryloxy, arylalkyl, halo or amino.

      16. The method of claim 15, wherein the cannabinoid is not a psychoactive cannabinoid.

      17. The method of claim 15 where the ischemic or neurodegenerative disease is an ischemic infarct, Alzheimer's disease, Parkinson's disease, and human immunodeficiency virus dementia, Down's syndrome, or heart disease.

      18. A method of treating a disease with a cannabinoid that has substantially no binding to the NMDA receptor, comprising determining whether the disease is caused by oxidative stress, and if the disease is caused by oxidative stress, administering the cannabinoid in a therapeutically effective antioxidant amount.

      19. The method of claim 18, wherein the cannabinoid has a volume of distribution of at least 1.5 L/kg and substantially no activity at the cannabinoid receptor.

      20. The method of claim 19, wherein the cannabinoid has a volume of distribution of at least 10 L/kg.

      (continued)

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • edbr:

      (continued for the last time! sorry!)

      21. The method of claim 1, wherein the cannabinoid selectively inhibits an enzyme activity of 5- and 15-lipoxygenase more than an enzyme activity of 12-lipoxygenase.

      22. A method of treating a neurodegenerative or ischemic disease in the central nervous system of a subject, comprising administering to the subject a therapeutically effective amount of a compound selected from any of the compounds of claims 9 through 13.

      23. The method of claim 22 where the compound is cannabidiol.

      24. The method of claim 22, wherein the ischemic or neurodegenerative disease is an ischemic infarct, Alzheimer's disease, Parkinson's disease, and human immunodeficiency virus dementia, Down's syndrome, or heart disease.

      25. The method of claim 24 wherein the disease is an ischemic infarct.

      26. The method of claim 1, wherein the cannabinoid is not an antagonist at the AMPA receptor.

      Again thanks.
      PS differences in the blood/brain barrier in individual chemicals can have huge differences from one person to another. Just an add.

      Thanks for reading and commenting.

    • 3 years ago
  • singrrr
    • 0
      singrrr  
    • With all of the studies showing how medical THC can help all kinds of people manage their pain one wonders why the government is so against it. When you have seen (as I have) a cancer patient wasting away, so sick that they can't eat or move and it is someone you care about, you will disagree with this countries policy on legal THC.

    • 3 years ago
  • arcticspirit
  • regularrf
    • 0
      regularrf  
    • This is a cure all and the government don't want us to have it. The pills don't work,nobody ever overdosed on
      pot,its impossible.Strength is an issue California grows one of the strongest back in the 60's 70's and early 80's
      the average weed was Mexican ,then you had Colombian gold, panama red, Ty sticks,and so on but the best is Maui weed . try finding any weed from back then is impossible.Now all the pot is grown in the U.S.A.
      and our war on drugs is not looking here.Prices ranged from $15 an oz to $60 an oz for the wheel chair weed back in the good old days...

    • 3 years ago
  • arcticspirit
  • Angel4truth
    • 0
      Angel4truth  
    • regularrf:

      Why do you say the pills don't work?
      Medical studies show it works for it's intended purpose, although the dose has to be monitored to avoid unwanted side effects, as in any medicine. That takes time.

      If you are taking thc for medical reasons did your doctor work with you to get the dosage where it would be effective? that's half the battle there.

      If you are saying the pills don't make you high? That is not the intended purpose for the chemical THC.
      Some people get that feel good thing. Some don't. But that's not what it's about.

      Cool that you know so much about pot. But I don't think you get the medical side. Read a spirt's comments. She has experience and medical training.

      My point is that it seems many want an excuse just to smoke pot.
      It's a personal decision, but the medical community in general thinks it's a pretty bad idea.

    • 3 years ago
  • ihateyou
    • 0
      ihateyou  
    • with the track record of the drugs the pharmeseuticals put out, i would rather smoke it or ingest it. i would never take anything from the drug companies.

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • ihateyou:

      That would be your decision. I totally respect that.

      Personally from the nightmare stories that I have hard from people taking "natural" remedies for different pain diseases alone or with medicines, I vote for the FDA researched specifically dosed and consistent quality product.

      I have created in 1994, and it is still very active, an online support group for people with chronic pain conditions. My buddy Dougal, coded it in perl and I did the html for the information website that went with it on different pain conditions.. all in word pad. Geez that was so long ago!

      But, over the years many people have found themselves in the ER or have had some pretty bad stuff happen just due to the lack of regulation, computability and quality of the "natural " products.

      My point is natural does not equal safe.

      We see this argument come up every year when new people come around. It's interesting.

      I tell people it's a personal choice.

      One girl told me she uses "e" to control her pain. I know why she did it, but didn't agree with it due to the same reason, lack or regulated doses & quality. But "e" gives a huge seratonin boost and that therefore reduces the pain, exhaustion and depression of people with chronic pain syndromes.

      Hey thanks for reading all.
      Have a good one :)

    • 3 years ago
  • LozRiva
    • 0
      LozRiva  
    • I'm thinking 'Why not' if the chemical THC can help those with conditions that are only treated with pain relief then being a more naturally occurring substance this could benefit many people who need help with their condition.

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • LozRiva:

      Possibly it's more "fun"? I really couldn't say. I did research enough to know that the symptoms the doctors were trying to control were indeed controlled with the synthetic THC.

      As of the 400 other "properties" the THC is the mind altering one that liberates seratonin (at least) .. I read that many if not most of that is harmful to your health. This is in the medical periodical side. But I only have 1 year of pre-med, due to getting too sick to attend more school.. but I learned much more as a patient actually. I am thinking in the point of pain control, because I have a "snow ball" of pain diseases.

      Angel might know more about the aids and chemo stuff.

    • 3 years ago
  • Psychedelic
    • 0
      Psychedelic  
    • Marinol does not work ! Thc is only one of the active ingredients in marijuana's 300+ compounds that helps users find relief from their suffering. Our bodies canabanoid system is linked to the many canabanoid chemicals in the plant. The canabanoid system is closely related to the pain centers of the body. Maranol contains no canabanoids like the eaten or smoked plant does and is much less effective for users, who also complain about the paranoid and uneasy feeling that pure Thc induces, unlike the plant form. Eat the pot if the doctor is against smoking it! No one said you had to smoke it. It's just a little tid bit of information for your research.

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • Psychedelic:

      Are you chronically ill and did you try this? I think they recommend 3-4 weeks and possible adjustments in creases/decreases to rid a person of the side effects that you are describing.

      If for fun, yes this would not be for you.

      Thanks for your input and for reading.

    • 3 years ago
  • Angel4truth
    • 0
      Angel4truth  
    • (continued)
      Now.. the
      Second group of people:

      2. People who have true need/reasons to use THC. These people totally benefit from the FDA synthetic THC. It works and is plentiful. Your doctor can give it to you with confidence of knowing exactly how much THC you will have, when to increase, etc.

      I had been helping a family member with health issues and here on current, medical use of THC comes up quite often. I know that she would not want to feel out of control or high. How would she get anything done?

      For medical purposes, people just want to feel better. They would like the medical benefits period. And if they are smart they will want something that a doctor can control, that will be the same every time they take it and is not bad for you.

      Face it, if you are sick enough to have to resort to THC, you are pretty fucked up... and the last thing you need in your life is that list of the shitty things that smoking pot WILL do to your body.
      Think about it, for medical reasons, people could be put on the THC for weeks, months, maybe years.

      If it is for control of chronic pain, for instance: THC is sometimes better than morphine, and with lower levels of meds in your system... over the course of years and years... it will be better for your organs that are processing the medicine.

      You can't forget that.

      So, people who need THC to live a decent life, they will be able to get the tablet and it's good.

      If you are using medical Marijuana as an excuse to produce, smoke, or get high ... well that is not the goal of medical Marijuana.

      That would be a totally different issue.

      Before now, I wasn't aware that it is already here, and quite possibly available in every state. It's FDA approved.

      I read several periodicals from teams of doctors researching the oral synthetic THC. Their findings were a little different from that of "regular" pot smokers.

      The medical research says that the THC is measured, accurate and does not expose the patient to possible extensive negative effects that smoking the natural plant has vs taking the THC pill.

      Pro Marijuana websites often say that the pill isn't as good as the plant because they don't get as "high" off it in so many words. Of course there are hundreds of chemicals the pill doesn't give you. There is a reason for that. The THC that they have synthesized does what it is intended to do.

      But because THC is the main mind altering ingredient in weed, the tablets must have warning that it can cause a "high" effect and not to drive, etc.

      So again that leads me to WHY?
      Do people just wanna get high legally and be able to buy product at the store instead of doing some shady drug deal?

      Or is there true concern for the health of people who the THC be able to have a constant and regulated way to get the THC?

      Which is it?
      It seems to be a cop out argument to keep saying make pot legal so we can use it for medical stuff when THC is concentrated and put into medicine already.

      Personally, I think there is a population of people just want to get high. And will use what ever excuse to make it easier.

      Then what about the argument that weed is better for the body than alcohol? well.. when they start prescribing vodka etc... then we can have that discussion.

      Again that's not a medical THC argument, but one for another forum.

      I'll be amazed if anyone reads all this. Hope it helps people with the issue. That is the GOAL.

    • 3 years ago
  • kewal91
  • Angel4truth
    • 0
      Angel4truth  
    • Image
    • I will try to post this without cursing and actually form ideas that hopefully convey info I have researched. Some of you know how hard that is for *me* ( gulp!).

      For me this feels like 2 separate issues.
      First group- most use "weed" regularly or sometimes.
      Goal?
      1. To make marijuana legal for everyone... going via the medical route, then passing laws for it to be legal.
      Anyone who has an ounce of common sense can see that anything about marijuana brings people out of the woodwork that say it's not dangerous, not a gateway drug, etc, It's amazing how many people use this drug and feel like it's "normal" and that it would be a good idea to legalize it.

      Studies of marijuana's mental effects show that the drug can impair or reduce short-term memory, alter sense of time, and reduce ability to do things which require concentration, swift reactions, and coordination, such as driving a car or operating machinery. This gets really bad if that is your medicine, think about it. If it's for medical use?

      The strength of today's marijuana is as much as ten times greater than the marijuana used in the early 1970s. With the tablets, this isn't an issue at all. They know exactly how much THC they are getting and it's very pure.
      For everyone that thinks they can hear/see etc. better when high on weed? NO. Sorry guys but No scientific evidence indicates that marijuana improves hearing, eyesight, and skin sensitivity.
      Maybe YOU THINK SO... BECAUSE of impaired senses. (shrugs)

      A chronic pain or a cancer patient has enough medically going on, but to have medicine that makes it so you can't drive safely or do other things, that isn't practical.

      Let's discuss the medical for a moment as it is "medical" weed right? One study found that the risk of heart attack more than quadruples in the first hour after smoking marijuana.
      Now do this long term? Think about it again.. not a good idea. Why pill vs smoke? OMG if this is your MEDICINE... chances are your body isn't all that resilient and the continued exposure of the smoked weed has more downfalls than I have room to write in this 4000 char space..

      Lets say your doctor tells you to smoke a joint every 6 hours... for example.. Marijuana smoke has been found to contain more cancer-causing agents than is found in tobacco smoke.

      Like I said, drug companies, doctors, hospitals have been taken to court and bled dry for less that this.

      So does this say that a healthy person can handle the poison that comes naturally with the product? Possibly. Would it make any sense to use that for medical? Hell NO... WTF are you thinking?

      Oh yeah and there are those who say something like cultures have been using it for millions of years, it is natural therefore good. OMG! NO. The discovery of the THC might have been cool and good for medicine. But in the long run, the plant hurts the patient.
      The pill will not.

      (2nd page below.. ran out of room)

    • 3 years ago
  • arcticspirit
    • 0
      arcticspirit  
    • Image
    • I am disabled and many people have told me that medical Marijuana is the latest greatest fix. So naturally I wanted to check this out.

      I talked to my doctor, and he said that he would never recommend smoking marijuana because the long term affects are devastating to health in general, especially if it is to be taken for a very long period of time.

      My doctor also told me that a "joint" usually isn't something that is regulated as having a set amount of THC, and it would be very irresponsible for a physician to advise a patient to go buy and smoke marijuana.

      I happen to have a violent allergic reaction to 2nd hand smoke of marijuana, as in I quit breathing. So my doctor doesn't recommend this treatment for me.

    • 3 years ago
  • kewal91
  • Dut
  • edbr
  • arcticspirit
    • 0
      arcticspirit  
    • Image
    • arcticspirit:

      Wow, great suggestions.

      What concerns us is exactly what in it makes me stop breathing. We haven't done a run with eating it, I have had the same reaction to other medicines as well, so this isn't the only or the first.

      I talked later about isolation of the ingredients, that could help people like me to be treated (for pain, migraines and more here). And the doctor may have better control over the elements.

      edbr posted some info and I expanded on it. Sorry it's long, but this is a serious topic and I think worthy of discussion.

      Thanks again guys.

      Oh has anyone seen people that stop breathing around 2nd hand smoke do ok taking it in other forms? I am curious for myself here.

    • 3 years ago
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