Hats Off to Dr. Hersch...More Evidence Creatine is an Effective Treatment for Huntington's Disease
- added December 27, 2007
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Creatine is a harmless nutritional supplement used by athletes.
It has just been found that it STOPS the progression of "untreatable and always fatal" Huntington's Disease..
Yes you heard right!
First; this study answered very important questions regarding creatine uptake into brain, and documented pharmacologic dosing levels. This is important because brain penetration is absolutely necessary for any (successful) Huntington�s drug. It can be argued that this type of drug/brain penetration testing should be required of any drug candidate prior to entering expensive phase III trials in Huntingtons.
Second; the authors used MRS, a radiologic technique reviewed previously at Lighthouse, ( NAA - biomarker for HD?) to measure creatine brain levels. MRS technique may prove useful as a sensitive measure of disease progression in the future. And sensitive measures of progression will shorten the time needed for clinical trials.
Third, they reported increased levels of 8OH2dG in the blood of Huntingtons people that was decreased with creatine use. Earlier reports had described elevation of this chemical in blood, urine and brain tissue of Huntington's mice. This chemical is a measure of DNA oxidative injury, and is elevated in other neurodegenerative diseases as well. The authors showed that creatine decreased the level of this marker in Huntingtons people, suggesting that creatine also decreased oxidative injury. They further speculate that 8OH2dG is a promising biomarker for studying drug response in HD.
This is a scientifically elegant study with many practical (and promising) results for HD people. This is the kind of trial we�d like to see more of.
-- LaVonne Veatch Goodman, M.D.
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.
Authors: S. M. Hersch, MD, PhD, S. Gevorkian, MSc, K. Marder, MD, MPH, C. Moskowitz, MS, A. Feigin, MD, M. Cox, MS, RN, P. Como, PhD, C. Zimmerman, RN, M. Lin, MD, L. Zhang, MD, A. M. Ulug, PhD, M. F. Beal, MD, W. Matson, PhD, M. Bogdanov, E. Ebbel, A. Zaleta, BA, Y. Kaneko, BA, B. Jenkins, PhD, N. Hevelone, MPH, H. Zhang, MS, H. Yu, MPH, D. Schoenfeld, PhD, R. Ferrante, PhD, MSc and H. D. Rosas, MD, MS
It has just been found that it STOPS the progression of "untreatable and always fatal" Huntington's Disease..
Yes you heard right!
First; this study answered very important questions regarding creatine uptake into brain, and documented pharmacologic dosing levels. This is important because brain penetration is absolutely necessary for any (successful) Huntington�s drug. It can be argued that this type of drug/brain penetration testing should be required of any drug candidate prior to entering expensive phase III trials in Huntingtons.
Second; the authors used MRS, a radiologic technique reviewed previously at Lighthouse, ( NAA - biomarker for HD?) to measure creatine brain levels. MRS technique may prove useful as a sensitive measure of disease progression in the future. And sensitive measures of progression will shorten the time needed for clinical trials.
Third, they reported increased levels of 8OH2dG in the blood of Huntingtons people that was decreased with creatine use. Earlier reports had described elevation of this chemical in blood, urine and brain tissue of Huntington's mice. This chemical is a measure of DNA oxidative injury, and is elevated in other neurodegenerative diseases as well. The authors showed that creatine decreased the level of this marker in Huntingtons people, suggesting that creatine also decreased oxidative injury. They further speculate that 8OH2dG is a promising biomarker for studying drug response in HD.
This is a scientifically elegant study with many practical (and promising) results for HD people. This is the kind of trial we�d like to see more of.
-- LaVonne Veatch Goodman, M.D.
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.
Authors: S. M. Hersch, MD, PhD, S. Gevorkian, MSc, K. Marder, MD, MPH, C. Moskowitz, MS, A. Feigin, MD, M. Cox, MS, RN, P. Como, PhD, C. Zimmerman, RN, M. Lin, MD, L. Zhang, MD, A. M. Ulug, PhD, M. F. Beal, MD, W. Matson, PhD, M. Bogdanov, E. Ebbel, A. Zaleta, BA, Y. Kaneko, BA, B. Jenkins, PhD, N. Hevelone, MPH, H. Zhang, MS, H. Yu, MPH, D. Schoenfeld, PhD, R. Ferrante, PhD, MSc and H. D. Rosas, MD, MS
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- dreamsofutopia
- 8 months ago
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