Skin cancer can be inherited: studies
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http://www.reuters.com/article/newsOne/idUSTRE5984VM20091010
NEW YORK (Reuters Health) - Want to reduce your risk of skin cancer? Wear sun screen, of course. But two new studies suggest that choosing your relatives carefully could also be helpful.One found that having an identical twin with melanoma increased a person's own risk of developing the disease much more than having a fraternal twin with this type of skin cancer. The other found that having a sibling or parent with one of several different types of non-melanoma skin cancer increased risk as well.
Several studies have suggested melanoma and other skin cancers run in families, but it can be difficult to tease out the difference between the influence of genes and environment. In the Australian study, Dr. Sri N. Shekar of the University of Queensland in Brisbane and his colleagues attempted to do so by looking at twin pairs in which at least one sibling had been diagnosed with melanoma.
They searched through thousands of cases of melanoma reported in Queensland and New South Wales and found 125 twin pairs. In four of the 27 identical twin pairs, both had melanoma, while three of the 98 fraternal twin pairs had both been diagnosed with the deadly skin cancer.
Based on these numbers, having an identical twin with melanoma increased a person's own risk of the disease nearly 10-fold, while melanoma associated with having a non-identical twin with the disease was roughly doubled.
This suggests, the researchers say, that some of the increased melanoma risk can be attributed to genes, in particular interactions between genes. They estimate that genes account for about half of the differences in risk between two people.
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Based on the findings, Hussain and colleagues conclude, a person's family history can be used to gauge their own skin cancer risk, and genetic studies could be a useful way to identify potential targets for treating or preventing the disease.
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- tags:
- Genetics, Studies, Skin Cancer
