Fat // Current TV

Low-Fat or Low Carb, Which is Best for You? | PriceDoc Talk

Low-fat or low-carb, which one do you prefer? Which one works best for you? Do you... more

pricedoc
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3 years ago
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Mariah Carey Is Awful Fat at the Oscars

Here’s Mariah Carey and her extra sized boobs attending the Oscars, because she... more

fashionista83
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3 years ago
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(VIDEO) Michael Moore: There’s Going to Be a Second Crash…And Glenn Beck Can F–k Off!!!

Michael Moore: There’s Going to Be a Second Crash (And Glenn Beck Can F–k... more

ctpatriot1970
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3 years ago
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Shock Jock Bubba the Love Sponge “Uses N-Word” Accused of Hate Call…”F**K HAITI!”

A professional wrestler says someone claiming to be radio host Bubba the Love Sponge... more

ctpatriot1970
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Your Fat is Killing You

Immune cells, adipose tissue conspire in obese people to boost levels of potentially unhealthy proteins
In the heavyweight division, immune cells embedded in fat pack some extra disease-causing punches, a new study shows.

Those punches involve potentially dangerous proteins linked to inflammation, heart disease and diabetes. Something in the adipose tissue, or fat, of overweight people primes immune cells called macrophages nestled within the tissue to release the proteins when the cells sense high levels of fat in the bloodstream, researchers report in the Feb. 24 Science Translational Medicine. The discovery may lead to treatments that could block disease formation in overweight or obese people.

Blood levels of free fatty acids, such as triglycerides, rise after a high-fat meal and, in obese people, are often constantly elevated to levels two to three times higher than normal, says Preeti Kishore, an endocrinologist at the Albert Einstein College of Medicine in New York City.

In the new study, Kishore and her colleagues show that these types of fat particles prod immune cells called macrophages to make PAI-1, a protein linked to heart disease. The protein, whose full name is plasminogen activator inhibitor-1, keeps blood clots, which can cause strokes or heart attacks, from breaking up.

The fatty acids also triggered the release of inflammation-causing proteins called TNF-alpha and IL-6, the researchers found. Inflammation caused by those and other proteins is thought to play a role in type 2 diabetes in obese people.

Scientists had already discovered that overweight and obese people have more macrophages in their fat tissue than do lean people. But, says Carey Lumeng, a pediatrician at the University of Michigan Medical School in Ann Arbor, “Nobody really knew — and we still don’t know — what exactly these macrophages are doing.”

The new study suggests that macrophages may tell fat tissue what is going on in the outside environment, which the macrophages sense through substances circulating in the blood, Lumeng says. And fat cells seem to communicate with macrophages, too, priming the immune cells to rapidly respond to dietary changes.

Kishore and her colleagues studied 30 overweight people, with an average body mass index of 28 (a BMI of 25 to 29.9 is overweight, and 30 or higher is considered obese) and an average age of 37. The researchers steadied the volunteers’ blood sugar levels, then injected an intravenous solution containing free fatty acids in concentrations that mimic the higher levels seen in obese people. The fat infusion is a standard formula used when feeding people intravenously. Within five hours, levels of PAI-1 and inflammatory proteins rose and impaired the volunteers’ sensitivity to insulin. Insulin insensitivity is a hallmark of type 2 diabetes.

The researchers took biopsies of stomach fat from the volunteers and found that macrophages, rather than fat cells, made the disease-linked proteins.

In further experiments with macrophages grown in the laboratory, Kishore and her colleagues discovered that free fatty acids alone didn’t prod macrophages to release PAI-1 or inflammatory chemicals. The cells also needed an as-yet-unidentified signal from fat cells before the macrophages would manufacture the proteins.

“Inflammation is a normal, healthy process, but under certain conditions it becomes inappropriately activated,” Kishore says. As people pack on pounds, their macrophages become more sensitive to dietary signals. “When these macrophages are activated,” she says, “they make more of these proteins that are bad for you.”Immune cells, adipose tissue conspire in obese people to boost levels of potentially... more

02
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What The Kevin Smith Scandal Means For The Future Of PR

Caroline McCarthy writes that Kevin Smith's response to being kicked off of a... more

atomiclegion
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3 years ago
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1 comment

Kevin Smith Challenges Southwest: Bring Airline Seat To Daily Show And I'll Sit In It

Kevin Smith continues to insist he is NOT too fat to fly Southwest Air. The airline... more

atomiclegion
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3 years ago
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35 comments

Awesome NSFW Kevin Smith Southwest Airlines Rant

So you may have heard that Kevin Smith was recently booted off a Southwest Airlines... more

atomiclegion
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3 years ago
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19 comments

Jamie Oliver's TED Prize wish: Teach Every Child About Food [video]

In this affecting video, TEDTalks Prize winner Jamie Oliver shares powerful stories... more

GrrlScientist
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3 years ago
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Director Kevin Smith 'too fat' to fly

He may like to make you laugh, but "Silent Bob" found nothing funny about... more

antoine_99
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3 years ago
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Kevin Smith deemed ‘too fat’ to fly

He may like to make you laugh, but “Silent Bob” found nothing funny about... more

ctpatriot1970
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3 years ago
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68 comments

Obese Children Twice as Likely to Die Before 55, so remember teasing the fat kid is for his own good

Obesity in children may pave the way to an early grave, a new study in the New England... more

bundlebear
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3 years ago
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Surgeon yells at a fatty

A foul-mouthed New Zealand surgeon has been reprimanded after swearing at a severely... more

akassan
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3 years ago
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MUMS SONG

about my mum the number person in my life I hope that you like it

peter_kanter
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3 years ago
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Michelle Obama HATES fat obese overweight kids!

Michelle Obama HATES fat obese overweight kids and wants to deny them food and make... more

NewWarriorMan
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3 years ago
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2 comments

‘Celebrity Fit Club’ In Their Underwear: K-Fed,Sebastian Bach, Nicole Eggert & More (PHOTOS)

VH-1’s new season of “Celebrity Fit Club” has premiered with a... more

ctpatriot1970
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3 years ago
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MY FAT DAUGHTERS (VIDEO): Michelle Obama Takes Fire for Discussing Malia, Sasha During Obesity Event…

Did Michelle Obama Send the Wrong Message With Obesity Comments? First Lady’s... more

ctpatriot1970
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3 years ago
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Ancient Birds Grew Fat and Lazy

The flighted ancestor of birds such as the Australian emu and cassowary became too... more

Maryleaf
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3 years ago
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Corn Syrup Advertisements! And other form of Nutricide!

CODEX ALIMENTARIUS Anyone??? (a whole nother dilema)... more

tonicsouls
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3 years ago
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Whole Foods Finds Way To Make Overweight Folk Feel Even More Self-Conscious

Whole Foods is offering bigger discounts -- from the current 20 percent to 30 percent... more

bundlebear
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3 years ago
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